Program

Registration

Opening Remarks by Eisuke Nishida

Session 1: Developmental timing and tempo (1)
Chair: Mitsuru Morimoto

S1-1
The Dynamics of Spinal Cord Development
James Briscoe (The Francis Crick Institute, UK)

S1-2
Adjusting the timing of mammalian development
Aydan Bulut-Karslioglu (Max Planck Institute for Molecular Genetics, Germany)

S1-3*
Same Clock Ticks Different Time: Molecular Insights into Temporal Scaling of Neurogenesis
Quan Wu (Kyoto University, Japan)

Coffee Break

Chair: Yumi Konagaya

S1-4
How ultradian gene expression oscillations can be used to measure time to differentiation
Nancy Papalopulu (University of Manchester, UK)

S1-5
Spatial regulation of extracellular matrix turnover rates guides macro-scale organ shape
Hironobu Fujiwara (RIKEN Center for Biosystems Dynamics Research, Japan)

Lunch

Poster Session 1
13:30-14:30 Presenters of odd numbered posters
14:30-15:00 Free discussion

Session 2: Biological time-defining mechanisms & technologies (1)
Chair: Mariko Okada

S2-1
Imaged-based prediction of single-cell transcriptomic phenotypes and beyond
Katsuyuki Shiroguchi (RIKEN Center for Biosystems Dynamics Research, Japan)

S2-2
No Flight of Fancy: Manifold-Constrained Statistical Inference on Cellular Process Dynamics
Gioele La Manno (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)

S2-3*
Time-Dependent Proliferation of Ventral Foregut Primes Enhancer Landscape for Organ-Specific Differentiation
Yan Fung Wong (University of Copenhagen, Denmark)

Coffee Break

Chair: Tomoya Kitajima

S2-4
Life-long Persistence of Nuclear Proteins and RNAs in the Brain
Martin Hetzer (Institute of Science and Technology Austria, Austria)

S2-5
Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3
Motomasa Tanaka (RIKEN Center for Brain Science, Japan)

S2-6
Landscapes of protein self-assembly and quality control across the lifespan
Daniel Jarosz (Stanford University, USA)

Social Gathering at BDR Lounge

Session 3: Developmental timing and tempo (2)
Chair: James Briscoe

S3-1
Temporal disparities between sexes creates sexual conflict that
contribute to the persistence of size variability
Maria Dominguez Castellano (Instituto de Neurociencias, Spain)

S3-2
Neuronal subtype specification in the developing nervous system by a common temporal transcription factor sequence
Andreas Sagner (FAU Erlangen-Nürnberg, Germany)

S3-3*
Tbx6/Ripply mechanism as a dynamic to static converter in somite segmentation
Taijiro Yabe (National Institute for Basic Biology, Japan)

Coffee Break

Chair: Yu-Chiun Wang

S3-4
Geometry and landscape for the segmentation clock
Paul François (Université de Montréal, Canada)

S3-5*
Towards reconstituting primate axial development in vitro
Cantas Alev (Kyoto University, Japan)

Group Photo & Lunch

Poster Session 2
13:00-14:00 Even numbered posters
14:00-14:30 Free discussion

Session 4: Dynamics in homeostasis
Chair: Hironobu Fujiwara

S4-1
Spermatogenic cycle and wave: self-organizing dynamical patterns of germ cell turnover in the mouse testis
Shosei Yoshida (National Institute for Basic Biology, Japan)

S4-2
Using 3D Epithelioids to study long-term tissue responses
Alberto Pradilla-Dieste (University of Cambridge, UK)

S4-3*
Growth of the maternal intestine during reproduction
Tomotsune Ameku (Imperial College London, UK)

Coffee Break

Chair: Takefumi Kondo

S4-4
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
Sa Kan Yoo (RIKEN Center for Biosystems Dynamics Research, Japan)

S4-5
Phase transition of epithelial tissues through ERK-mediated mechanical feedback
Tsuyoshi Hirashima (National University of Singapore, Singapore)

Presentation by Zoom
S4-6
Somatic mutation in normal tissues

Inigo Martincorena (Wellcome Sanger Institute, UK)

Session 5: Hallmarks and drivers of aging
Chair: Katsuyuki Shiroguchi

S5-1
Towards healthy ageing: Investigating the regulation of protein aggregation
Della David (Babraham Institute, UK)

S5-2
Aging-related changes to stem cells and the stem cell niche
Leanne Jones (University of California, San Francisco, USA)

S5-3
Cell biological mechanisms of aging-associated aneuploidy in eggs
Tomoya Kitajima (RIKEN Center for Biosystems Dynamics Research, Japan)

Coffee Break

Chair: Sa Kan Yoo

S5-4
Clock Aging: Molecular basis for age-related functional decline
Hikari Yoshitane (The University of Tokyo, Japan)

S5-5
NFkB Dynamics And Transcriptional Regulation In Cellular Senescence
Mariko Okada (Osaka University, Japan)

Lunch

Session 6: Biological time-defining mechanisms & technologies (2)
Chair: Della David

S6-1
Energetics of Biological Systems
Jonathan Rodenfels (Max Planck Institute for Molecular Cell Biology and Genetics, Germany)

S6-2*
Restoration of biological age during prolonged fasting-refeeding modulated by fasting-responsive linker histone
Kazuto Kawamura (Max Planck Institute for Biology of Ageing, Germany)

S6-3*
Dietary Availability Acutely Governs Puberty Timing via Hypothalamic Neural Circuit
Kazunari Miyamichi (RIKEN Center for Biosystems Dynamics Research, Japan)

Presentation by Zoom
S6-4
Cytosine methylation dynamics across the lifespan in mammals
Steve Horvath (Altos Labs, UK)

Closing remarks by James Briscoe