Program

Registration

Welcome address by Eisuke Nishida

Introductory remarks by Mitsuru Morimoto

Session 1: Recapitulation of early human development

S1-1

Naive human PSCs model pre- to post-implantation development

Yasuhiro Takashima (Center For iPS Cell Research and Application, Kyoto University, Japan)

S1-2
Bioengineering human embryo and organ models
Jianping Fu (University of Michigan, USA)

S1-3

Pioneer factor-mediated epigenetic mechanisms in cell fate control

Makiko Iwafuchi (Center for Stem Cell & Organoid Medicine, Cincinnati Children’s Hospital Medical Center, USA)

S1-4*

Functional analysis of asynchronous Hes1 oscillations in the neural tube formation

Yuki Maeda (RIKEN Center for Brain Science, Japan)

Coffee Break

Session 2: Organoids-on-device

S2-1

Recapitulating spatial-temporal microenvironments to mimic mechano-chemical cues during neural tube development

Masaya Hagiwara (RIKEN Center for Biosystems Dynamics Research, Japan)

S2-2

Innovations in Bottom-Up Tissue Engineering with Microfluidic Technology for Organoid Research

Shoji Takeuchi (The University of Tokyo, Japan)

S2-3*

Establishment of a hiPSC-derived liver-on-a-chip for personalized drug metabolism studies

Isabel Tamargo-Rubio (University Medical Center Groningen, The Netherlands)

Keynote Talk 1

KT1-1

Towards the Era of Functional Organoids

Toshiro Sato (Keio University School of Medicine, Japan)

Banquet at BDR Lounge (optional)

Session 3: Urinary system organoids

S3-1

Enhancement of Bladder Organoids Through Interaction Between Urotheial Epithelium and Visceral Mesenchyme

Minoru Takasato (RIKEN Center for Biosystems Dynamics Research, Japan)

S3-2

TBA

Núria Montserrat Pulido (Institute for Bioengineering of Catalonia (IBEC), Spain)

S3-3

Integrating organoid technology and two/three-dimensional MPS

Ryuji Yokokawa (Kyoto University, Japan)

Coffee Break

Session 4: The foregut and hindgut derived organoids 1

S4-1

Organoid system for trachea/esophagus development modeling

Mitsuru Morimoto, Aaron Zorn, Keishi Kishimoto (RIKEN Center for Biosystems Dynamics Research, Japan and Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical Center, USA)

S4-2

Engineering tissue complexity into human PSC-derived gastrointestinal organoids

James Wells (Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, USA)

Flash Talk by Sponsors

- Leica Microsystems K.K.

- Yamaha Motor Co., Ltd.

Group Photo & Lunch

Poster Session 1

13:10-14:10 Presenters of odd-numbered posters

14:10-14:30 Free discussion

Session 5: The foregut and hindgut derived organoids 2

S5-1

Organoid-guided Precision Hepatology

Takanori Takebe (Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, USA)

S5-2

TBA

Jason Spence (The University of Michigan, USA)

S5-3*

Investigating the mechanisms by which SMAD6 mutations cause tracheoesophageal birth defects

Vivien Sauer (Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical Center, USA)

Coffee Break

Session 6: Approaches to creating advanced organoids

S6-1

Eri Hashino (Indiana University School of Medicine, USA)

S6-2

Making MOChi: Taking cues from the embryo to build Midfacial Organoids on a Chip

Samantha Brugmann (Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, USA)

S6-3*

Modelling human development using pancreatic organoid

Jonathan A. Brassard (Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children’s Hospital Medical Center (CCHMC), Cincinnati, USA)

(Speaker Dinner)

Session 7: Clinical applications of organoids

S7-1

Characterization of mesenchymal support for in vivo GI organoid engraftment

Michael A. Helmrath (Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, USA)

S7-2

Primary lung alveolar organoids as a method for mechanistic regenerative biology and disease modeling

William Zacharias (Cincinnati Children’s Hospital Medical Center, USA)

S7-3

The creation of heart organoids targeted for medical applications

Hidetoshi Masumoto (RIKEN Center for Biosystems Dynamics Research, Japan)

Coffee Break

Session 8: Customized chemical-physical environment for organoids

S8-1

TBA

Kristi S. Anseth (University of Colorado, Boulder, USA)

S8-2

TBA

Sharad Ramanathan (Harvard University, USA)

S8-3*

Emergent Tissue Morphogenesis in Limb Development: A Synergy of 2.5D, 3D Cultures and Mathematical Modeling

Rio Tsutsumi (Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Japan)

Lunch

Poster Session 2

13:10-14:10 Presenters of Even-numbered posters

14:10-14:30 Free discussion

Session 9: Brain organoid

S9-1

Creating dorso-ventral spinal cord organoid

Hideya Sakaguchi (BDR-Otsuka Pharmaceutical Collaboration Center, RIKEN Center for Biosystems Dynamics Research, Japan)

S9-2*

Light-induced spatial ciliary signaling regulates the dorsal/ventral regionalization of human brain organoids

Issei S. Shimada (Nagoya City University, Japan)

Keynote Talk 2

KT2-1

Exploring the human gut with bioengineered models and single-cell technologies

J. Gray Camp (Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland)

Closing Remarks