スピーカー紹介

Anne Grapin-Botton is a professor at the Danish Stem Cell Center at the university of Copenhagen. She is also a director at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden where she will move fully in the summer 2019. Her lab focuses on understanding how pancreatic cells differentiate during mouse and human embryogenesis, and uses this knowledge to differentiate pancreatic organoids and beta cells from human stem cells in vitro. Anne Grapin-Botton and her group made important contributions to extracellular signals inducing the pancreas, transcriptional relays involved in pancreatic progenitor expansion and transcriptional control of differentiation. They used mouse genetics, lineage tracing, live imaging and single cell transcription assays to clarify the dynamics of decision processes at the single-cell level and the impact of the cellular and organ architecture. Organoids enable her lab to study the principles of self-organization in a minimalist system mimicking development.

Anne has trained with Nicole Le Douarin in Paris for her PhD, with Doug Melton in Harvard for her post-doc and has previously been a principal investigator in Lausanne (Switzerland) at the ISREC and EPFL.