Program

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Monday, March 3 (Day 1) | Tuesday, March 4 (Day 2) | Wednesday, March 5 (Day 3)

Monday, March 3 (Day 1)

*Selected talk

Time	Speakers
9:00-9:55	Registration
9:55-10:00	Opening Address by Kazunari Miyamichi
10:00-10:05	Welcome Remarks by Eisuke Nishida
Session 1 Chair: Genshiro Sunagawa
10:05-10:30	S1-1 Cell types of adult mouse brain: definition and experimental access Bosiljka Tasic (Allen Institute, USA)
10:30-10:55	S1-2 Life-stage-dependent neural circuit remodeling in mice: Foundations of physiological and behavioral plasticity Kazunari Miyamichi (RIKEN Center for Biosystems Dynamics Research, Japan)
10:55-11:10	S1-3* VMH-NR5A1 Regulates Food Intake in Adults Teppei Fujikawa (UT Southwestern Medical Center, USA)
11:10-11:25	S1-4* Does Sleep Arise from the Trajectory of Neuronal States? Shoi Shi (University of Tsukuba, Japan)
11:25-11:50	Coffee Break
Session 2 Chair: Yasushi Okada
11:50-12:15	S2-1 How RocA and DMDA-PatA target eIF4A: insights into their mechanism of action Takuhiro Ito (RIKEN Center for Biosystems Dynamics Research, Japan)
12:15-12:30	S2-2* Finding Rules for Sequence-Dependent Coexistence of Protein Condensates Kyosuke Adachi (RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program, Japan)
12:30-13:40	Lunch Poster Flash Talk 1 (13:20-13:40) Chair: Kazunari Miyamichi
13:40-15:10	Poster Session 1 13:40-14:40 Presenters of odd-numbered posters 14:40-15:10 Free discussion
Session 3 Chair: Sa Kan Yoo
15:10-15:35	S3-1 Deciphering the systemic functions of protein arginine methylation: A small change makes a physiological difference during aging Akiyoshi Fukamizu (Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan)
15:35-16:00	S3-2 Systemic extracellular acidification as a novel hallmark of ageing Helena Cochemé (MRC Laboratory of Medical Sciences (LMS), UK)
16:00-16:25	S3-3 Shifting to the healthy life by early-life dietary manipulation Fumiaki Obata (RIKEN Center for Biosystems Dynamics Research, Japan)
16:25-16:55	Coffee Break
Session 4 Chair: Miki Ebisuya
16:55-17:20	S4-1 Building Blocks to Program Morphogenesis Wendell A. Lim (University of California San Francisco, USA)
17:20-17:45	S4-2 Microvessel-on-a-Chip: Tuning Vessels for Tissue Design Yukiko T. Matsunaga (The University of Tokyo, Japan)
17:45-18:00	S4-3* Self-organization of embryonic stem cells into a reproducible embryo model through epigenome editing S. Ali Shariati (University of California, Santa Cruz, USA)
18:00-20:30	Social Gathering at BDR Lounge

Tuesday, March 4 (Day 2)

*Selected talk

Time	Speakers
Session 5 Chair: Teruki Honma
9:30-9:55	S5-1 Structural Life Science Research Using Fragment Molecular Orbital Method Kaori Fukuzawa (Osaka University, Japan)
9:55-10:20	S5-2 Use of FMO Analysis to Refine and Interpret Cryo-EM Structures Toru Sengoku (Yokohama City University, Japan)
10:20-10:45	S5-3 Guiding Medicinal Chemistry with Fragment Molecular Orbital (FMO) Method Alexander Heifetz (Sygnature Discovery, UK)
10:45-11:15	Coffee Break
Session 6 Chair: Shuichi Onami
11:15-11:35	S6-1 Can Aging be Solved? Lessons from C. elegans David Gems (University College London, UK)
11:35-11:50	S6-2* The Signaling Buffering System that Ensures Lifelong Maintenance of Intestinal Stem Cells May Nakajima-Koyama (Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan)
11:50-13:00	Group Photo & Lunch Poster Flash Talk 2 (12:40-13:00) Chair: Miki Ebisuya
13:00-14:30	Poster Session 2 13:00-14:00 Presenters of Even-numbered posters 14:00-14:30 Free discussion
Session 7 Chair: Kazunari Miyamichi
14:30-14:55	S7-1 Reopening critical periods with psychedelics: basic mechanisms and therapeutic opportunities Gül Dölen (University of California, Berkeley, USA)
14:55-15:20	S7-2 Neural Mechanisms Underlying the Representation of Others Teruhiro Okuyama (Institute for Quantitative Biosciences (IQB), The University of Tokyo, Japan)
15:20-15:45	S7-3 Neural circuit mechanisms for sexually dimorphic innate behaviors Nirao Shah (Stanford University, USA)
15:45-16:10	Coffee Break
Session 8 Chair: Mitsuru Morimoto
16:10-16:35 REMOTE TALK	S8-1 Engineering Next-Generation Organoids Matthias Lütolf (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
16:35-17:00	S8-2 Co-induction and self-organization of skeletal muscle and endothelial cells from bovine embryonic stem cells Marina Sanaki-Matsumiya (Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan)
17:00-17:25	S8-3 Multiplexed Immunofluorescence Imaging Reveals Dynamic Cell Cycle Regulation Coupled with Intestinal Stem Cell Differentiation Yumi Konagaya (RIKEN Center for Biosystems Dynamics Research, Japan)
17:25-17:50	S8-4 Microengineered biomimicry of human physiological systems Dan Huh (University of Pennsylvania, USA)
17:50-18:05	S8-5* Emergence of Embryo-Like Organization upon Artificial Input to hPSC epithelium Zhe Wang (Kyoto University, Japan)
	(Speaker Dinner)

Wednesday, March 5 (Day 3)

*Selected talk

Time	Speakers
Plenary Talk Chair: Yasushi Okada
9:30-9:55	PT-1 TBA Hiroaki Kitano (Okinawa Institute of Science and Technology / The Systems Biology Institute, Japan)
Session 9 Chair: Yumi Konagaya
9:55-10:20	S9-1 Cytoplasmic fluidization triggers dormancy breaking in fission yeast spores Kazhiro Aoki (Kyoto University, Japan)
10:20-10:45	S9-2 Cardiovascular diseases and drugs: where are we with hiPSC models? Christine Mummery (Leiden University Medical Center, The Netherlands)
10:45-11:10	Coffee Break
Session 10 Chair: Fumiaki Obata
11:10-11:35	S10-1 Mechanisms of healthy aging in the longest-lived rodent, the naked mole-rat Kyoko Miura (Kumamoto University, Japan)
11:35-12:00	S10-2* Neonatal gut microbial propionate prevents onset of later bronchial asthma Hiroshi Ohno (RIKEN Center for Integrative Medical Sciences, Japan)
12:00-12:05	Poster Awards
12:05-12:10	Closing Remarks by Miki Ebisuya

The 2025 RIKEN BDR-CuSTOM Joint Organoid Symposium “Integrated Organoid Science: Stem cells, Engineering, Medicine,” will be held at the same venue immediately following the BDR Symposium. We invite you to consider joining this event as well if you are interested.